abstract：:The diagnostic approach to the compromised host with CNS infection depends on an analysis of the patient's clinical manifestations of CNS disease, the acuteness or subacuteness of the clinical presentation, and an analysis of the type of immune defect compromising the patient's host defenses. Most patients with CNS in...

journal_title：Infectious disease clinics of North America

authors： Cunha BA

更新日期：2001-06-01 00:00:00

abstract：:Vaccine recommendations continue to evolve as a result of new vaccines, safety considerations, changing disease incidence (e.g., polio), and public health priorities. The pace of discovery is accelerating and advisory committees will need to respond accordingly. Each vaccine, new or old, will be required to earn its p...

journal_title：Infectious disease clinics of North America

authors： Gardner P,Peter G

更新日期：2001-03-01 00:00:00

abstract：:Immune dysregulation and immunosuppression regimens impact on the ability of transplant recipients to respond to immunizations. The distinct challenges of immunizations to benefit stem cell transplant recipients and solid organ transplant recipients are discussed separately. Recommended vaccines for stem cell transpla...

journal_title：Infectious disease clinics of North America

authors： Molrine DC,Hibberd PL

更新日期：2001-03-01 00:00:00

abstract：:Infection with the human immunodeficiency virus type 1 (HIV-1) results in progressive loss of immune function marked by depletion of the CD4+ T-lymphocytes, leading to opportunistic infections and malignancies characteristic of AIDS. Although both host and viral determinants influence the rate of disease progression, ...

journal_title：Infectious disease clinics of North America

authors： Vergis EN,Mellors JW

更新日期：2000-12-01 00:00:00

abstract：:Amebiasis is a widespread parasitic disease caused by Entamoeba histolytica. This protozoan organism is the third leading parasitic cause of death in the developing world and is an important health risk to travelers in endemic areas. Amebiasis most commonly results in asymptomatic colonization of the gastrointestinal ...

journal_title：Infectious disease clinics of North America

authors： Hughes MA,Petri WA Jr

更新日期：2000-09-01 00:00:00

abstract：:Changes that occur in the pharmacology of drugs in the elderly must be considered in the use of antimicrobial agents. Although absorption of orally administered drugs is not affected in a significant way, renal function decreases, drug-drug interactions increase, compliance with regimens may be decreased, and drug tox...

journal_title：Infectious disease clinics of North America

authors： Stalam M,Kaye D

更新日期：2000-06-01 00:00:00

abstract：:The number of species that comprise the family of Bartonellaceae, genus Bartonella, has recently increased from one to 11 species, five of which have been associated with different diseases and syndromes in humans. The rapidly growing number of human pathogens has led several investigators to regard bartonellosis and ...

journal_title：Infectious disease clinics of North America

authors： Maguiña C,Gotuzzo E

更新日期：2000-03-01 00:00:00

abstract：:HTLV-1 infection is endemic in several Latin American countries. HTLV-1-associated myelophathy/tropical spastic paraparesis (HAM/TSP) and adult T-cell leukemia lymphoma (ATLL) are emerging diseases in the region. Documented risk factors for acquiring the virus include breast-feeding, contaminated blood transfusion, an...

journal_title：Infectious disease clinics of North America

authors： Gotuzzo E,Arango C,de Queiroz-Campos A,Istúriz RE

更新日期：2000-03-01 00:00:00

abstract：:Oral lesions are easily visualized and often are signs of systemic diseases. Clinical diagnosis of viral and fungal infections can sometimes be confusing because many lesions will have similar clinical presentations. This article reviews the more common viral- and fungal-associated lesions found in the oral cavity in ...

journal_title：Infectious disease clinics of North America

authors： Glick M,Siegel MA

更新日期：1999-12-01 00:00:00

abstract：:The central nervous system and systemic complications of bacterial meningitis cause significant morbidity and mortality. This article offers insight into the clinical features, pathogenesis, and management of these complications. In many instances, the improved outcome of intervention is based on clinical suspicion an...

journal_title：Infectious disease clinics of North America

authors： Rauf SJ,Roberts NJ Jr

更新日期：1999-09-01 00:00:00

abstract：:The ability of a host to sense invasion by a pathogenic organism, and to respond appropriately to control infection, is paramount to survival. To that end, an array of receptors and binding proteins has evolved as part of the innate immune system to detect Gram-negative bacteria. This article reviews the role of CD14,...

journal_title：Infectious disease clinics of North America

authors： Ingalls RR,Heine H,Lien E,Yoshimura A,Golenbock D

更新日期：1999-06-01 00:00:00

abstract：:The treatment of severe sepsis and septic shock remains a challenge as we approach the next millennium. Although more attention is being given to guidelines and care pathways for sepsis, these are unfortunately based primarily on consensus opinion. Additional research into supportive interventions in this potentially ...

journal_title：Infectious disease clinics of North America

authors： Dellinger RP

更新日期：1999-06-01 00:00:00

abstract：:This article focuses on the use of immunoglobulin variable regions, including Id, anti-Id, anticlonotypes, and Id engineering as putative vaccines and vaccine strategies for infectious diseases; and specific discussion of Id systems involving antigenic determinants associated with potentially pathogenic organisms. ...

journal_title：Infectious disease clinics of North America

authors： Hefty PS,Kennedy RC

更新日期：1999-03-01 00:00:00

abstract：:Antigens located in the midgut of the tick are hidden from the host's immune system. Egg production of ticks can be reduced when ticks are fed on animals vaccinated with midgut antigens of the tick, and a subunit vaccine formulated with the recombinant antigen Bm86 is now available that can reduce the number of ticks ...

journal_title：Infectious disease clinics of North America

authors： Lee R,Opdebeeck JP

更新日期：1999-03-01 00:00:00

abstract：:Within the past several years, the decision to employ outpatient parenteral antibiotic therapy (OPAT) is driven by adequacy of insurance, availability of appropriate resources within the community, and the clinical stability of the patient. Current dogma is that virtually any diagnosed disease can be treated outside t...

journal_title：Infectious disease clinics of North America

authors： Brown RB

更新日期：1998-12-01 00:00:00

abstract：:Pneumonia remains a major cause of morbidity and mortality in the immunocompromised host. The type and timing of immunosuppression will predispose the patient to infections with certain pathogens. This article discusses the types of immunosuppression and their infectious and noninfectious implications. Key points of t...

journal_title：Infectious disease clinics of North America

authors： Collin BA,Ramphal R

更新日期：1998-09-01 00:00:00

abstract：:As the result of a formidable effort, the recent TB epidemic in the United States has abated; however, major questions remain as the risk of TB diminishes. Will we maintain an adequate public health effort not only to prevent another resurgence of TB but also to renew our pursuit of TB elimination? Do we have the will...

journal_title：Infectious disease clinics of North America

authors： Griffith DE

更新日期：1998-09-01 00:00:00

abstract：:Compromised travelers represent a diverse and challenging group of individuals. They include HIV-infected patients who are at risk for potentially adverse reactions to immunizations, and new exposures to enteric water-borne opportunistic pathogens associated with chronic infections. Such travelers may encounter unfami...

journal_title：Infectious disease clinics of North America

authors： Mileno MD,Bia FJ

更新日期：1998-06-01 00:00:00

abstract：:KS is a major cause of morbidity and mortality among AIDS patients and a treatment problem in the sporadic cases that are not associated with HIV. All four forms of the disease are linked to a newly described herpesvirus, HHV-8 or KSHV, via strong epidemiologic associations and biologic plausibility as a causal agent....

journal_title：Infectious disease clinics of North America

authors： Greenblatt RM

更新日期：1998-03-01 00:00:00

abstract：:Improvements in donor selection, testing of donors for markers of infection, and viral inactivation of plasma-derived products have helped reduce the risk of transfusion-associated infections, including hepatitis B (HBV), hepatitis C (HCV), and human immunodeficiency viruses (HIV). The potential for transmission of em...

journal_title：Infectious disease clinics of North America

authors： Chamberland M,Khabbaz RF

更新日期：1998-03-01 00:00:00

abstract：:The emergence of antimicrobial resistance among several common bacterial pathogens requires that clinical microbiology laboratories have the ability to promptly and accurately recognize resistance in patients' isolates. Laboratories have several options for performing routine susceptibility testing, including the brot...

journal_title：Infectious disease clinics of North America

authors： Jorgensen JH

更新日期：1997-12-01 00:00:00

abstract：:Recent decades have witnessed the emergence and spread of parasites resistant to standard drug therapies, particularly malaria. Chloroquine-resistant Plasmodium falciparum has now spread to most malarial areas, and resistance to other antimalarial drugs, including mefloquine and sulfadoxine-pyrimethamine, have become ...

journal_title：Infectious disease clinics of North America

authors： Barat LM,Bloland PB

更新日期：1997-12-01 00:00:00

abstract：:Urinary tract infections are common during infancy and childhood but are easily overlooked because of the unspecific symptoms. Prevention of renal scarring and its potential long-term consequences is possible but requires an increased awareness of the diagnosis, the imaging revealing anomalies within the urinary tract...

journal_title：Infectious disease clinics of North America

authors： Hansson S,Martinell J,Stokland E,Jodal U

更新日期：1997-09-01 00:00:00

abstract：:Traditionally, imaging of renal infections was largely through a multimodality approach. Excretory urography, ultrasonography, nuclear scintigraphy, and CT all played major roles; however, in recent years, CT has increased in prominence in the imaging and evaluation of renal infection. Part of the reason for this tren...

journal_title：Infectious disease clinics of North America

authors： Kaplan DM,Rosenfield AT,Smith RC

更新日期：1997-09-01 00:00:00

abstract：:Occupational transmission of hepatitis B virus (HBV), hepatitis C virus, and HIV has been documented. The risk for occupationally transmitted infection varies for these three viruses. Despite effective pre- and postexposure prophylaxis for HBV and recent recommendations for postexposure chemoprophylaxis after an HIV e...

journal_title：Infectious disease clinics of North America

authors： Cardo DM,Bell DM

更新日期：1997-06-01 00:00:00

abstract：:We have proposed a model in which the initiation of human parturition in the presence of infection is controlled by the host. Systemic maternal infections such as pyelonephritis or localized infections such as deciduitis can trigger parturition by the activation of the monocyte and macrophage system in peripheral bloo...

journal_title：Infectious disease clinics of North America

authors： Gomez R,Romero R,Edwin SS,David C

更新日期：1997-03-01 00:00:00

abstract：:Acute bacterial endocarditis (ABE) is clinically distinct from subacute bacterial endocarditis in terms of pathologic virulence, acuteness and severity of illness, complications, and prognosis. The term infectious endocarditis may be useful as a general term but conveys no meaningful clinical information. ABE presents...

journal_title：Infectious disease clinics of North America

authors： Cunha BA,Gill MV,Lazar JM

更新日期：1996-12-01 00:00:00

abstract：:Anti-varicella-zoster virus serum antibody assays and their use in vaccine development are described. Of particular interest are FAMA and neutralization assays and the gpELISA. These and other assays are compared and summarized in terms of characteristics including biologic relevance, sensitivity, specificity, and sui...

journal_title：Infectious disease clinics of North America

authors： Krah DL

更新日期：1996-09-01 00:00:00

abstract：:Septic shock is a common life-threatening problem, usually presenting with fever, tachycardia, tachypnea, and often a source of infection. The cardiac index is increased, with a decreased systemic vascular resistance, and a reversibly decreased ejection fraction with an increased end diastolic volume. The myocardial d...

journal_title：Infectious disease clinics of North America

authors： Toney JF,Parker MM

更新日期：1996-06-01 00:00:00

abstract：:In the ICU, fever can be expected to accompany an extensive number of conditions of both infectious and noninfectious etiologies. It is crucial to identify the precise cause of fever, because certain conditions in either category may be life-threatening, whereas others require no treatment at all. It is important to r...

journal_title：Infectious disease clinics of North America

authors： Cunha BA,Shea KW

更新日期：1996-03-01 00:00:00

abstract：:Cytomegalovirus (CMV) continues to be responsible for a substantial fraction of the morbidity and mortality that follows organ transplantation. The three major consequences of CMV infection are CMV disease (encompassing a range of clinical illness), superinfection with opportunistic pathogens, and injury to the transp...

journal_title：Infectious disease clinics of North America

authors： Hibberd PL,Snydman DR

更新日期：1995-12-01 00:00:00

abstract：:The emergence of resistance to antimicrobial agents continues to be a major problem among both nosocomial and community-acquired pathogens. Bacteria employ a variety of strategies to avoid the inhibitory effects of antibiotic agents, and have evolved highly efficient means for the dissemination of resistance traits. T...

journal_title：Infectious disease clinics of North America

authors： Fraimow HS,Abrutyn E

更新日期：1995-09-01 00:00:00

abstract：:Since the introduction of the floroquinolones for clinical use in the late 1980s, they have been used successfully for a large number of clinical situations. As experience accumulates, the indications and optimal use of these agents gradually become more clear. Unfortunately, two of the pathogens for which these agent...

journal_title：Infectious disease clinics of North America

authors： Hendershot EF

更新日期：1995-09-01 00:00:00

abstract：:Global eradication of smallpox, elimination of poliomyelitis in the Western Hemisphere, and a 90% decrease in Haemophilus influenzae meningitis in the Western Hemisphere mark some of the achievements of immunization programs around the world. Yet many serious problems continue to exist, particularly in the developing ...

journal_title：Infectious disease clinics of North America

authors： Grossman M

更新日期：1995-06-01 00:00:00

abstract：:At the heart of imminent healthcare reform are the future physicians of this decade. Medical educators will want to stimulate a desire within students to practice humanitarian, cost-effective, community-oriented primary care. Further studies to examine the effects of medical student experiences in international electi...

journal_title：Infectious disease clinics of North America

authors： Chiller TM,De Mieri P,Cohen I

更新日期：1995-06-01 00:00:00

abstract：:A wide range of soft-tissue infections can occur in diabetic patients, the consequences of which can be devastating. Early recognition and intervention, which may involve both surgical and medical approaches, can improve clinical outcomes. ...

journal_title：Infectious disease clinics of North America

authors： Sentochnik DE

更新日期：1995-03-01 00:00:00

abstract：:Various nontuberculous mycobacteria can cause infection of skin and soft tissues. These organisms are also known as atypical mycobacteria, anonymous mycobacteria, and mycobacteria other than tuberculosis. These organisms are much more common causes of cutaneous infection than Mycobacterium tuberculosis. Infections cau...

journal_title：Infectious disease clinics of North America

authors： Dalovisio JR,Pankey GA

更新日期：1994-09-01 00:00:00

abstract：:No practitioner can hide from HIV. Patients infected with HIV are treated in every type of practice setting as the number of cases increases at an alarming rate. This article provides 10 basic guidelines for the care of HIV-infected patients. ...

journal_title：Infectious disease clinics of North America

authors： Glatt AE

更新日期：1994-06-01 00:00:00

abstract：:It appears incontestable that there is a link between genital ulcer disease and HIV infection. On the one hand the natural history and response to therapy of syphilis, HSV-2, and chancroid are all modified by the immunosuppressive effects of HIV infection. On the other hand, HIV transmission is probably facilitated by...

journal_title：Infectious disease clinics of North America

authors： Augenbraun MH,McCormack WM

更新日期：1994-06-01 00:00:00

abstract：:This article updates the epidemiologic situation of HIV and AIDS infection and summarizes the most common clinical manifestations in Latin American countries. As of December 1992, a total of 59,723 AIDS cases had been reported to the Pan American Health Organization from Mexico, Central America, South America, and the...

journal_title：Infectious disease clinics of North America

authors： Murillo J,Castro KG

更新日期：1994-03-01 00:00:00